| Autor: | J. Laurent, N. Bachot, Saadia Kerdine, Marc Pallardy, I. Gaspard, Hervé Lebrec, M.T. Guinnepain |
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| Rok vydání: | 1999 |
| Předmět: |
Drug
business.industry Health Toxicology and Mutagenesis medicine.medical_treatment T cell media_common.quotation_subject Thiazolidine Cell Biology Toxicology medicine.disease chemistry.chemical_compound Immune system Cytokine medicine.anatomical_structure chemistry Immunology Cytotoxic T cell Medicine business Allergic contact dermatitis CD8 media_common |
| Zdroj: | Cell Biology and Toxicology. 15:57-62 |
| ISSN: | 0742-2091 |
| DOI: | 10.1023/a:1007554707345 |
| Popis: | Allergic contact dermatitis is induced by a wide variety of drugs that trigger specific immune responses following topical exposure. Identified chemical stuctures involved in such reactions include the mercuric and thiosalicylic acid groups of thimerosal, the diphenylketone group of the anti-inflammatory drug ketoprofen, the amide or ester structure of local anesthetics, and the side-chain and thiazolidine ring of β-lactams. The T cell responses to such compounds involve CD4+ and CD8+ αβ+ T lymphocytes and also CD4–/CD8– γδ+ T cells. Although "T helper 2" cytokine production by drug-specific human T cells from patients with allergic contact dermatitis has been described, T helper 1-like and T cytotoxic 1-like responses clearly play key roles in this cutaneous reaction. |
| Databáze: | OpenAIRE |
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