Conditional survival in gallbladder carcinoma: Results from the SEER 11 dataset
| Autor: | Clifton D. Fuller, Charles R. Thomas, Samuel J. Wang, G.D. Starling |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Journal of Clinical Oncology. 24:4130-4130 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | 4130 Background: Traditionally, survival is reported as 5-or10-yr survival from diagnosis. However, the 5-yr probability of demise changes considerably with each year survived in many cancers. Clinicians may utilize conditional survival to estimate risk over time. Gallbladder cancer is a rare neoplasm with little extant data with regard to risk assessment for patients with one or more years survival post-therapy. The specific aim of this study is to assess the conditional survival of patients with gallbladder adenocarcinoma using data extracted from the Surveillance, Epidemiology, and End Results (SEER 11) Program. Methods: Cumulative observed survival rates were calculated by the life-table method using SEER data for 3744 patients with histologically confirmed gallbladder adenocarcinoma (diagnosed from 1973 to 2001). On the basis of the cumulative survival estimates, we derived the conditional survival, defined as the calculated probability of survival having already survived a specified number of years from diagnosis, with sub-stratification by extent of disease. Results: Conditional survival calculations reveal dismal 5-year survival at diagnosis (Figures 1 and 2), with increasing probability of survival per each year survived. However, conditional survival plateaus at approximately 60–70% at 4 years post-diagnosis, with little change in conditional survival until 10 years. Conclusions: This dataset represents the largest pooled data for gallbladder carcinoma, and is markedly larger than any given institutional series. Consequently, while imperfect, this data represents a useful estimate for patients with considerable post-diagnosis survival. Although the disease-free survival outcomes for patients with gallbladder adenocarcinoma remain low, for those patient surviving even 1 year post-diagnosis, conditional survival estimates increase rapidly. [Table: see text] No significant financial relationships to disclose. |
| Databáze: | OpenAIRE |
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