A high-throughput and high peak capacity narrow-bore parallel segmented flow column strategy for the liquid chromatography-tandem mass spectrometry analysis of organic contaminants in water
| Autor: | R. Andrew Shalliker, Arianne Soliven, Andrés Pérez-Parada, Horacio Heinzen, Lucía Pareja |
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| Rok vydání: | 2020 |
| Předmět: |
Matrix (chemical analysis)
Detection limit Materials science Chromatography Calibration curve Liquid chromatography–mass spectrometry General Chemical Engineering General Engineering Ion suppression in liquid chromatography–mass spectrometry High-performance liquid chromatography Ion source Analytical Chemistry Bar (unit) |
| Zdroj: | Analytical Methods. 12:239-246 |
| ISSN: | 1759-9679 1759-9660 |
| DOI: | 10.1039/c9ay02370d |
| Popis: | This study highlights the development of a high peak capacity, high-throughput (HTP) approach for a target list of 62 organic contaminants in an environmental river water matrix on a HPLC conventional 400 bar system. Key separation metrics were evaluated: (a) peak capacity, (b) total analysis time and (c) mobile phase consumption. An average peak width of 0.10 min with a total analysis time (inclusive of the column wash and re-equilibration) of 10 minutes revealed the increased productivity and performance of the parallel segmented flow (PSF) column technology HPLC-MS strategy, comparable to UHPLC peak widths and analysis times, achieved at a significantly lower backpressure ( |
| Databáze: | OpenAIRE |
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