Synthesis, structure elucidation, DNA interaction, biological evaluation, and molecular docking of an isatin-derived tyramine bidentate Schiff base and its metal complexes

Autor:	Sivasangu Sobha, Liviu Mitu, Natarajan Raman
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Schiff base Denticity chemistry Absorption spectroscopy Stereochemistry Isatin General Chemistry pUC19 Cyclic voltammetry Antibacterial activity DNA
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 143:1019-1030
ISSN:	1434-4475 0026-9247
Popis:	Three new transition metal complexes [CuL2Cl2], [NiL2Cl2], and [ZnL2Cl2], where L = Schiff base derived from isatin (1H-indole-2,3-dione) and tyramine (4-(2-aminoethyl)phenol), have been synthesized and characterized spectroscopically. The binding properties of these complexes with calf thymus DNA have been investigated by use of electronic absorption spectroscopy, viscosity measurement, cyclic voltammetry, and molecular docking analysis. Moreover, these complexes have been found to promote the cleavage of pUC19 DNA from the supercoiled form I to the open circular form II in the presence of hydrogen peroxide. The newly synthesized compounds were screened for antibacterial activity and subjected to molecular docking studies for inhibition of the enzyme Staphylococcus aureus sortase-A, which is a novel target for antibacterials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::84a4a720c4955cb2a01a86d78fa0e8c5 https://doi.org/10.1007/s00706-011-0699-8 Zobrazit plný text záznamu Full text from SpringerLink