Analysis of simulated data: Evidence for genetic and environmental effects

Autor:	D. Timothy Bishop, Gillian P. Crockford, Mark M. Iles, L. Kathryn Durham
Rok vydání:	1999
Předmět:	Genetics Linkage disequilibrium education.field_of_study Epidemiology Disequilibrium Population Replicate Disease Transmission disequilibrium test Biology Genetic linkage medicine medicine.symptom education Genetics (clinical) Genetic association
Zdroj:	Genetic Epidemiology. 17:S527-S532
ISSN:	0741-0395
DOI:	10.1002/gepi.1370170785
Popis:	We approached the simulation as though it were an international study with similar but not identical information being collected from different populations. In keeping with this we analyzed one replicate from each population. Initially we examined the risk of disease in relatives of cases to determine whether the disease appeared to be “more genetic” in one population than in the others and we examined the evidence for environmental risk factors in each population. Non-parametric linkage analysis and transmission/disequilibrium testing (TDT) were used to search for loci linked to the disease in each population. Using these methods we identified several candidate regions for a susceptibility gene which on examination of the answers are explicable in terms of the underlying model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::84975b350285793e9bdd1768acc9ef4f https://doi.org/10.1002/gepi.1370170785 Zobrazit plný text záznamu Plný text