Differential Response of Liver and Kidney Adenine Nucleotide Translocase and Pyruvate Dehydrogenase Activity to Alloxan Diabetes
| Autor: | Patricia McLean, Michael R. Ball |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Pyruvate decarboxylation
medicine.medical_specialty Kidney Pyruvate dehydrogenase kinase Chemistry Liver and kidney Pyruvate dehydrogenase phosphatase medicine.disease Pyruvate dehydrogenase complex Biochemistry Endocrinology medicine.anatomical_structure Diabetes mellitus Internal medicine medicine Adenine nucleotide translocase |
| Zdroj: | Enzyme. 29:15-20 |
| ISSN: | 2504-2564 0013-9432 |
| Popis: | Adenine nucleotide translocase (EC 3.6.1.3.), pyruvate dehydrogenase (active and total forms, EC 1.2.4.1) and the long chain acyl CoA content were measured in liver and kidney from normal and alloxan-diabetic rats. The long chain acyl CoA content was significantly increased in liver, but not in kidney, in the diabetic group. Adenine nucleotide translocase activity was decreased in liver and raised in the kidney of alloxan-diabetic rats relative to the control group. Pyruvate dehydrogenase (active) was inhibited to a similar degree in both tissues in diabetes. The results are discussed in the light of the possible regulatory role of long chain acyl CoA and the diverse metabolic demands of the two tissues in diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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