| Autor: |
Peter Krieg, Gerhard Fürstenberger |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Lipoxygenases in Inflammation ISBN: 9783319277646 |
| DOI: |
10.1007/978-3-319-27766-0_8 |
| Popis: |
The skin is the primary barrier between the external environment and the internal milieu of the host protecting the body from physical and chemical insults and injury and preventing the loss of water. An active lipid metabolism and fatty acid-derived oxylipins are crucially involved in the structural integrity and functionality of the skin. Among them are lipoxygenases (LOX)-derived autacoids generated by an abundant and diverse cutaneous LOX metabolism. LOX products fulfill substantial functions in epithelial tissue homeostasis, inflammation as the general skin response to external damage, wound healing, and disease-related processes including numerous inflammatory skin conditions and the development of skin cancer. Recent results point to a critical role of a distinct LOX pathway in the development and maintenance of the epidermal barrier. This review focuses on the activities and mechanisms of actions of individual LOX-derived oxylipins, and the dysregulation of the corresponding LOX enzymes in diseased skin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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