Synthesis and Antioxidant Activity of Ethyl 2-Amino-6-cyano-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylates and 3-Amino-4-oxo-7-phenyl-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carbonitriles

Autor:	A. A. Aghekyan, R. E. Muradyan, G. G. Mkryan, Henry A. Panosyan, G. M. Buniatyan
Rok vydání:	2020
Předmět:	Diethylamine Antioxidant Pyrimidine 010405 organic chemistry medicine.medical_treatment Organic Chemistry Hydrazine Benzothiophene chemistry.chemical_element 01 natural sciences Sulfur Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound chemistry medicine heterocyclic compounds Gewald reaction Hydrate
Zdroj:	Russian Journal of Organic Chemistry. 56:440-445
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428020030124
Popis:	Gewald reaction of 4-oxo-1-phenylcyclohexane-1-carbonitrile with ethyl cyanoacetate and elemental sulfur in the presence of diethylamine afforded ethyl 2-amino-6-cyano-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate which was treated with a series of acid chlorides to obtain the corresponding 2-amido derivatives. Condensation of the latter with hydrazine hydrate gave new fused benzothienopyrimidines. The synthesized compounds were screened for antioxidant activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::837415d1eb55a2140e6c176f7a45151c https://doi.org/10.1134/s1070428020030124 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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