Synthesis, crystal structure, photophysical property and bioimaging application of a series of Zn(II) terpyridine complexes
| Autor: | Le Zhou, Hui Wang, Di Li, Dexiang Feng, Jun Zhang, Yan Wei, Jing He, Fengze Cai, Yunjun Wu, Zhijun Feng |
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| Rok vydání: | 2019 |
| Předmět: |
Membrane permeability
010405 organic chemistry Chemistry Organic Chemistry Crystal structure 010402 general chemistry 01 natural sciences Fluorescence 0104 chemical sciences Analytical Chemistry Inorganic Chemistry Metal Crystallography chemistry.chemical_compound visual_art visual_art.visual_art_medium Molecule Terpyridine Absorption (chemistry) Biological imaging Spectroscopy |
| Zdroj: | Journal of Molecular Structure. 1194:157-162 |
| ISSN: | 0022-2860 |
| Popis: | Metal complexes are expected to serve as efficient imaging probes to understand the biological process. In this work, a series of new ZnX2 (X = Cl, Br, I) complexes (DMT-ZnCl2, DMT-ZnBr2 and DMT-ZnI2) based on terpyridine were synthesized and fully characterized. X-ray crystal structure analysis demonstrate that the coplanarity within the molecules presents a certain regularity (DMT-ZnCl2 > DMT-ZnBr2 > DMT-ZnI2). The photophysical studies demonstrate the absorption bands showed a regular bathochromic-shift from DMT-ZnCl2 to DMT-ZnI2 along with the fluorescence intensity and the quantum yields decreasing. Biological tests reveal that all the Zn(II) complexes possess low cytotoxicity, good membrane permeability and good photostability, and exhibit a strong fluorescence in the cytosolic space in living Hela cells. Given mentioned above, the Zn(II) complexes can act as a promising candidate for biological imaging agent. |
| Databáze: | OpenAIRE |
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