Modulatory difference due to injury pattern in the moderate-TBI brain: Effective connectivity of working memory from preliminary findings
| Autor: | Jalan Munshi Abdullah, Wen Jia Chai, A I Abd Hamid |
|---|---|
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Journal of Physics: Conference Series. 1497:012007 |
| ISSN: | 1742-6596 1742-6588 |
| DOI: | 10.1088/1742-6596/1497/1/012007 |
| Popis: | Traumatic brain injury could cause cognitive deficits due to brain network disruption. The present study examined the effective connectivity of working memory in a group of moderate-TBI participants and making comparison with healthy controls. Group-level results of the n-back task with four levels of cognitive load (0-, 1-, 2-, and 3-back) identified activation in regions that corresponded with past literature of working memory, including the bilateral inferior occipital gyri, superior parietal lobules, and superior frontal gyri that were specified as regions of interest for subsequent dynamic causal model specification. The modulatory inputs were differentially defined in six models for every participant. Bayesian model selection directed to different winning models between the groups based on injury patterns. The moderate-TBI group with left hemisphere injury favoured connectivity involving a bottom-up left-to-right modulation, whereas the healthy group and TBI group with injuries involving both hemispheres preferred the connectivity model with a bottom-up modulation that is bilateral and bidirectional. The left-lateralized modulatory pattern reported in the moderate-TBI participants implies the role of the left hemisphere in attending to cognitively demanding tasks, especially in individuals with a disrupted neural network. Future studies could work on expanding the connectivity analyses based on the current finding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|