Long-Term Double-Blind Comparative Study of Ibopamine Versus Placebo in the Treatment of Chronic Congestive Heart Failure
| Autor: | J.-G. Kayanakis |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Inotrope
medicine.medical_specialty business.industry Vasodilation Hydralazine medicine.disease Placebo humanities Heart failure Internal medicine Ibopamine cardiovascular system medicine Cardiology Prazosin cardiovascular diseases Enalapril business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Heart Failure Mechanisms and Management ISBN: 9783642635090 |
| DOI: | 10.1007/978-3-642-58231-8_23 |
| Popis: | Conventionally, congestive heart failure (CHF) has been treated with digitalis glycosides and diuretics to improve cardiac performance and reduce symptoms of congestion [1–3]. Recently, treatment of CHF has been advanced through the use of vasodilators and in particular angiotensin-converting enzyme inhibitors (ACEs) [4–6]. In addition to improving exercise tolerance and symptoms. a controlled clinical trial in severely disabled (NYHA class IV) CHF patients found a reduction in mortality when enalapril was added to various treatment regimens [7]. Mortality was also shown to be reduced in patients treated with the vasodilator hydralazine in combination with nitrates but not the alpha-blocker prazosin [4]. As the role of vasodilation in CHF has become more clear, the role of inotropy has become increasingly controversial. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|