The Immunologic Response To Injury
| Autor: | John A. Mannick, James A. Lederer, Mary L. Rodrick |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Resuscitation Thermal injury business.industry Organ dysfunction Inflammation medicine.disease Systemic inflammatory response syndrome Immunity Shock (circulatory) Immunology Medicine Surgery medicine.symptom business Multiple organ dysfunction syndrome Intensive care medicine |
| Zdroj: | Journal of the American College of Surgeons. 193:237-244 |
| ISSN: | 1072-7515 |
| DOI: | 10.1016/s1072-7515(01)01011-0 |
| Popis: | Research on the immune consequences of shock and trauma by multiple laboratories over more than 20 years has resulted in the following paradigm, which is currently accepted by most investigators in this field: serious traumatic or thermal injury is quickly followed, after initial resuscitation, by the systemic inflammatory response syndrome (SIRS) which, in a sizeable minority of patients, will lead inexorably to multiple organ dysfunction syndrome (early MODS), with an attendant high mortality. The majority of seriously injured patients survive the initial SIRS response without developing early MODS, and after a period of relative clinical stability, manifest a compensatory antiinflammatory response syndrome (CARS) with suppressed immunity and diminished resistance to infection. Resultant infection and its attendant inflammation in turn can lead to multiple organ dysfunction (late MODS) and death (Fig. 1). This paradigm has several implications of potential importance in interpreting the sometimes conflicting results of research in this area |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|