| Popis: |
Clinical inhalation studies typically take place in whole-body exposure chambers with tightly controlled atmospheric conditions and with exposure protocols intended to be representative of actual community or occupational exposure conditions, with respect to pollutant concentration, exposure duration, and activity patterns (Hackney et al. 1985). Chamber studies usually employ free-living volunteers drawn from segments of the population which are considered to be especially at risk from exposure to the pollutant(s) in question. The special risk may relate to increased responsiveness or decreased functional reserve, as in patients with chronic cardiopulmonary disease. Alternatively, the special risk may relate to unusually high inhaled doses of pollutants, as in healthy manual laborers and athletes who experience high ventilation rates for long periods of time. |
