Green Synthesis of Silver Nanoparticles by Plumbago indica and Its Antitumor Activity Against Dalton's Lymphoma Ascites Model

Autor: A. Veeraraj, R. Moses Packiaraj, K.P. Srinivasakumar, C.K. Balavigneswaran, Y. Natheer Hassan, S. Prakash, T. Sujin Jeba Kumar
Rok vydání: 2013
Předmět:
Zdroj: BioNanoScience. 3:394-402
ISSN: 2191-1649
2191-1630
Popis: In this present study, silver nanoparticles (AgNPs) were synthesized by aqueous extract of Plumbago indica and were confirmed by UV–Vis spectrophotometer. XRD and TEM characterization revealed that AgNPs were spherical, with the average size ranging from 50 to 70 nm. The AgNPs showed excellent activity against all types of bacteria and most fungi examined in the experiment. IC50 value was found to be 600 nM. This AgNPs also showed dose-dependent cytotoxicity against DLA cells. AgNPs significantly increased the survival time in the mice model with survival days about 34(±3) days in comparison with controls 17(±1) days. AgNPs also decreased the volume of ascitic fluid in bearing mice, thereby returning body weight to normal. Elevated white blood cell and platelet counts in ascitic fluid of the bearing mice were brought to near normal level. These results suggest that the AgNPs synthesized from aqueous extract of P. indica may be a good antimicrobial and cost-effective alternative for the treatment against several and angiogenesis-related disorders.
Databáze: OpenAIRE
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