Dinitrosyl iron complexes with glutathione in rat myocardial tissue during regional ischemia and postischemic reperfusion

Autor:	Alexander A. Timoshin, Anatoly F. Vanin, I. M. Studneva, Oleg I. Pisarenko, L. I. Serebryakova, D. Yu. Drobotova, Tskitishvili Ov, Enno K. Ruuge
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Reactive oxygen species Myocardial ischemia Myocardial tissue Postischemic reperfusion Biophysics Ischemia Glutathione Rat heart Pharmacology medicine.disease Infarct size chemistry.chemical_compound chemistry Biochemistry medicine
Zdroj:	Biophysics. 55:999-1005
ISSN:	1555-6654 0006-3509
DOI:	10.1134/s0006350910060199
Popis:	Injection of dinitrosyl iron complexes with glutathione at the onset of 40-min regional myocardial ischemia in rat was shown to exert a clear cardioprotective action by decreasing the infarct size and suppressing the cardiac rhythm disturbance. After introducing the preparation, its effective accumulation with protein thiol-containing ligands in the myocardial tissue was registered be the EPR method. It was also found that in postischemic reperfusion, the rate of decrease in the content of these complexes in the ischemic area increases, which reflects effective scavenging of short-lived reactive oxygen species by the dinitrosyl iron complexes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::81763217b523edc6d04bbbbd6a03b24e https://doi.org/10.1134/s0006350910060199 Zobrazit plný text záznamu Full text from SpringerLink