Quantitative and qualitative adaptations of muscle fibers to glucocorticoids
| Autor: | Marco Alessandro Minetto, Emanuela Longa, Roberto Bottinelli, Valentina Agoni, Maria Antonietta Pellegrino, Giovanna Motta, Danilo Miotti, Rizwan Qaisar |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test Physiology Vastus lateralis muscle business.industry Cellular and Molecular Neuroscience Endocrinology Physiology (medical) Internal medicine Myosin Biopsy medicine biology.protein Creatine kinase Neurology (clinical) medicine.symptom Myopathy business Dexamethasone Muscle contraction Steroid Myopathy medicine.drug |
| Zdroj: | Muscle & Nerve. 52:631-639 |
| ISSN: | 0148-639X |
| Popis: | Introduction: The aim of this study was to understand the effects of short-term glucocorticoid administration in healthy subjects. Methods: Five healthy men received dexamethasone (8 mg/day) for 7 days. Vastus lateralis muscle biopsy and knee extension torque measurement were performed before and after administration. A large number of individual muscle fibers were dissected from the biopsy samples (pre-administration: n = 165, post-administration: n = 177). Results: Maximal knee extension torque increased after administration (∼13%), whereas both type 1 and type 2A fibers had decreased cross-sectional area (type 1: ∼11%, type 2A: ∼17%), myosin loss (type 1: ∼18%, type 2A: ∼32%), and loss of specific force (type 1: ∼24%, type 2A: ∼33%), which were preferential for fast fibers. Conclusion: Short-term dexamethasone administration in healthy subjects elicits quantitative and qualitative adaptations of muscle fibers that precede (and may predict) the clinical appearance of myopathy in glucocorticoid-treated subjects. Muscle Nerve 52: 631–639, 2015 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text