Perinatal Malnutrition Programs Sympathoadrenal and Hypothalamic-Pituitary-Adrenal Axis Responsiveness to Restraint Stress in Adult Male Rats
| Autor: | Laurence Dufourny, B. Blondeau, I. Avril, Bernadette Breant, Jean Lesage, Christine Laborie, Jean-Paul Dupouy, François Bernet |
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| Rok vydání: | 2002 |
| Předmět: |
Cortisol secretion
medicine.medical_specialty Sympathetic nervous system Endocrine and Autonomic Systems Offspring Endocrinology Diabetes and Metabolism Adrenocorticotropic hormone Cellular and Molecular Neuroscience Corticotropin-releasing hormone chemistry.chemical_compound Endocrinology medicine.anatomical_structure Mineralocorticoid receptor chemistry Corticosterone Internal medicine medicine Psychology Hypothalamic–pituitary–adrenal axis |
| Zdroj: | Journal of Neuroendocrinology. 14:135-143 |
| ISSN: | 0953-8194 |
| DOI: | 10.1046/j.0007-1331.2001.00753.x |
| Popis: | In humans, an altered control of cortisol secretion was reported in adult men born with a low birth weight making the hypothalamic-pituitary-adrenal (HPA) axis a possible primary target of early life programming. In rats, we have recently shown that maternal food restriction during late pregnancy induces both an intrauterine growth retardation and an overexposure of fetuses to maternal corticosterone, which disturb the development of the HPA axis in offspring. The first aim of this work was to investigate, in adult male rats, whether perinatal malnutrition has long-lasting effects on the HPA axis activity during both basal and stressful conditions. Moreover, as the HPA axis and sympathetic nervous system are both activated by stress, the second aim of this work was to investigate, in these rats, the adrenomedullary catecholaminergic system under basal and stressful conditions. This study was conducted on 4-month-old male rats malnourished during their perinatal life and on age-matched control animals. Under basal conditions, perinatal malnutrition reduced body weight and plasma corticosteroid-binding globulin (CBG) level but increased mineralocorticoid receptor (MR) gene expression in CA1 hippocampal area. After 30 min of restraint, perinatally malnourished (PM) rats showed increased plasma noradrenaline, adrenocorticotropin hormone (ACTH) and corticosterone concentrations similarly as controls, but calculated plasma-free corticosterone concentration was significantly higher and adrenaline level lower than controls. During the phase of recovery, PM rats showed a rapid return of plasma ACTH and corticosterone concentrations to baseline levels in comparison with controls. These data suggest that in PM rats, an elevation of basal concentrations of corticosterone, in face of reduced CBG and probably increased hippocampal MR lead to a much larger impact of corticosterone on target cells that mediate the negative-feedback mechanism on the activities of both the HPA axis and sympathoadrenal one. |
| Databáze: | OpenAIRE |
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