A novel efficient route to hexahydrodibenzofuran derivatives

Autor:	F. Kigabo, Marie-Paule Jouannetaud, J.‐C. Jacquesy, Christian Berrier
Rok vydání:	1991
Předmět:	chemistry.chemical_classification Reaction mechanism Addition reaction Ketone Organic Chemistry Hydrogen fluoride Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Anhydrous Phenol Enone
Zdroj:	Tetrahedron. 47:6681-6688
ISSN:	0040-4020
Popis:	Synthesis of 2 and 4-aryl cyclohexenones and of hexahydrodibenzofuran derivatives is described. In anhydrous hydrogen fluoride at 0°C, 4-hydroxy-4 methylcyclohex-2 en-1 one 2 reacted to yield ketone 7 (43%). Reaction of ketone 2 with parabromophenol 13b in HF gave ketone 6 (40%) at −20°C and ketone 6 (35%) and 7 (13%) at 0°C. Under similar conditions ketone 2 reacted with phenol 3a to yield 2 and 4 arylated ketones 4a (4%), 5 (a+b) (25%) and 9a (5%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::80db92342f15330f92ad74a0f667b75b https://doi.org/10.1016/s0040-4020(01)82320-6 Zobrazit plný text záznamu