Progesterone Promotes Survival of the Rat Corpus Luteum in the Absence of Cognate Receptors1
| Autor: | Carlos M. Telleria, Geula Gibori, Alicia A. Goyeneche, Ricardo P. Deis |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
endocrine system
medicine.medical_specialty Programmed cell death urogenital system Prostaglandin Ovary Cell Biology General Medicine Biology Luteal phase Endometrium chemistry.chemical_compound Endocrinology medicine.anatomical_structure Reproductive Medicine chemistry Apoptosis Internal medicine Progesterone receptor medicine Corpus luteum hormones hormone substitutes and hormone antagonists reproductive and urinary physiology |
| Zdroj: | Biology of Reproduction. 68:151-158 |
| ISSN: | 1529-7268 0006-3363 |
| Popis: | Progesterone production by the corpus luteum (CL) is essential for preparation of the endometrium for implantation and for the maintenance of gestation. Progesterone modulates its own production and opposes functional luteal regression induced by exogenous agents, such as prostaglandin F2α. In the present study, we evaluated whether progesterone is also capable of interfering with the process of structural luteal regression, which is characterized by a decrease in weight and size of the gland because of programmed cell death (i.e., apoptosis). We have found that a low number of luteal cells undergo apoptosis throughout gestation. On the day of parturition, but following the initial decline in endogenous progesterone production, a small increase in the number of luteal cells undergoing cell death was observed. This increase in apoptotic cells continued postpartum, reaching dramatic levels by Day 4 postpartum, and was accompanied by a marked decrease in average luteal weight. We have established th... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|