Leishmanicidal Activity and Immunomodulatory Effect of a Mixture of Lupenone and β-Caryophyllene Oxide
| Autor: | Rosa Moo-Puc, Rajeev Rai, Glendy Polanco-Hernández, Karla Fernández-Martín, Maira Rubí Segura-Campos, Alberto Giménez-Turba, Giulia Getti, Karla Y. Acosta-Viana, Victor Arana-Argáez, Efrain Salamanca, Julio César Torres-Romero, Luis M. Peña-Rodríguez |
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| Rok vydání: | 2021 |
| Předmět: |
Infectivity
Traditional medicine biology 010405 organic chemistry Chemistry Oxide Leishmania biology.organism_classification Sesquiterpene 01 natural sciences Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound parasitic diseases Ic50 values Viability assay β caryophyllene General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Revista Brasileira de Farmacognosia. 31:199-206 |
| ISSN: | 1981-528X |
| Popis: | Evaluation of the leishmanicidal activity of different mixtures of β-caryophyllene oxide and lupenone against Old and New World Leishmania spp. showed that both the pure β-caryophyllene oxide and the 1:4 mixture of lupenone and β-caryophyllene oxide are similarly active against promastigotes of L. amazonensis, L. braziliensis, L. mexicana, L. tropica, and L. aethiopica, with IC50 values ranging from 14 to 39.3 μg/ml, and reduce the infectivity of macrophages by L. mexicana and L. tropica. However, the 1:4 mixture of lupenone and β-caryophyllene oxide showed a better selectivity index than the pure sesquiterpene and increased production of NO, H2O2, and cytokines; these results suggest that the 1:4 mixture of terpenoids has both leishmanicidal activity and an immunomodulator effect, without affecting cell viability. |
| Databáze: | OpenAIRE |
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