Hexokinase Domain Containing 1 (HKDC1) Gene Variants and their Association with Gestational Diabetes Mellitus in a South Indian Population
| Autor: | Viswanathan Mohan, Venkatesan Radha, Ranjit Mohan Anjana, Sekar Kanthimathi, Dhandapani Laasya, Samuel Liju |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genetics medicine.medical_specialty Hexokinase endocrine system diseases nutritional and metabolic diseases Genome-wide association study Biology medicine.disease HKDC1 female genital diseases and pregnancy complications DNA sequencing Gestational diabetes 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Endocrinology chemistry Internal medicine medicine Glucose homeostasis Allele Gene Genetics (clinical) |
| Zdroj: | Annals of Human Genetics. 80:241-245 |
| ISSN: | 0003-4800 1076-2264 |
| DOI: | 10.1111/ahg.12155 |
| Popis: | Summary Hexokinase domain containing 1 (HKDC1), a novel human hexokinase gene, is known to affect glucose metabolism and was shown to have a strong association with 2-h plasma glucose in pregnant women in a recent genome wide association study. This study aimed to evaluate the association of these regulatory variants of HKDC1 (rs1076224, rs4746822, rs2394529 and rs9645501) with gestational diabetes mellitus (GDM) in a South Indian population. The regulatory variants of HKDC1 were genotyped in unrelated 500 women with GDM and 510 non-GDM individuals by using the MassARRAY system and by direct DNA sequencing. The minor alleles of the HKDC1 gene regulatory variants, namely rs10762264 and rs4746822, showed a significant association with GDM and these alleles conferred as much as 1.24 and 1.34 times higher risk for GDM, respectively. This is the first study to demonstrate the association of HKDC1 genetic variants with susceptibility to GDM. |
| Databáze: | OpenAIRE |
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