Hepatic Enzyme Induction by Antiepileptic Drugs in the Elderly Male
| Autor: | Robin J Flynn, Chaidong Cho |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test biology business.industry Biochemistry (medical) Clinical Biochemistry digestive system Endocrinology Internal medicine Liver enzyme Additive drug effects medicine biology.protein Alkaline phosphatase High alkaline phosphatase Enzyme inducer Liver function tests business |
| Zdroj: | Laboratory Medicine. 21:823-826 |
| ISSN: | 1943-7730 0007-5027 |
| DOI: | 10.1093/labmed/21.12.823 |
| Popis: | To investigate the enzyme induction effects of antiepileptic drugs (AEDs) on laboratory tests in a group of elderly males, a panel of liver function tests was run on 99 patients receiving AEDs and the results were compared with 102 age-matched patients who were not receiving AEDs. Gammaglutamyl transferase (GGT) levels were abnormal in 57 patients (58%) receiving AEDs, in contrast to 13 control patients (13%) (P>.001). Thirtysix patients receiving AEDs had abnormally high alkaline phosphatase (ALP) levels, compared with 13 controls (P>.001). Forty-six patients receiving AEDs had a GGT/ALP ratio greater than 1.0 versus 10 control patients (P>.001). Alcohol had a minimal additive effect to the enzyme induction. The elderly patients receiving AEDs tended to experience less GGT induction, but ALP induction was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|