Selektive Acylierungen von 3(5)-Alkyl-5(3)-amino-1H-pyrazolen und eine neue Pyrazolo[5,1-c]-1,2,4-triazol-Synthese
Autor: | G. Lutze, Burkhard Schulz, M. Ramm, Erich Dr Wolff, Klaus Kirschke |
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Rok vydání: | 1994 |
Předmět: | |
Zdroj: | Liebigs Annalen der Chemie. 1994:1037-1042 |
ISSN: | 1099-0690 0170-2041 |
Popis: | Selective Acylations of 3(5)-Alkyl-5(3)-amino-1H-pyrazoles and a New Pyrazolo[5,1-c]-1,2,4-triazole Synthesis (Z)-5-Amino-1-[1-(hydroximino)alkyl]-1H-pyrazoles 3 have been synthesized by acylation of 3(5)-alkyl-5(3)-amino-1H-pyrazoles 1 with nitrile oxides. The tosylation of the hydroxyimino group of 3 to (Z)-5-amino-1-[1-(p-tosyloximino)alkyl]-1H-pyrazoles 4 and the subsequent acetylation of the 5-amino group give (E)- and (Z)-5-acetamido-1-[1-(p-tosyloximino)alkyl]-1H-pyrazoles 5, which undergo cyclization under basic conditions to pyrazolo[5,1-c]-1,2,4-triazoles 6, 7 or 8. |
Databáze: | OpenAIRE |
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