Bisphosphonate treatment delays stress fracture remodeling in the rat ulna
| Autor: | Wendy Lee Kelly, Andy Wu, Lisa Kidd, Mark R. Forwood, Nicholas R. Cowling |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Stress fractures Callus formation business.industry medicine.medical_treatment Dentistry Bisphosphonate medicine.disease Bone resorption Bone remodeling Resorption Bone Density Conservation Agents Endocrinology Internal medicine medicine Orthopedics and Sports Medicine business Ulna Fractures |
| Zdroj: | Journal of Orthopaedic Research. 29:1827-1833 |
| ISSN: | 0736-0266 |
| DOI: | 10.1002/jor.21464 |
| Popis: | Because bisphosphonates (BPs) are potent inhibitors of bone resorption, we hypothesized that they would retard direct remodeling of stress fractures. The aim of this study was to determine the effect of risedronate on direct remodeling and woven bone callus formation following stress fracture formation in the rat ulna. In 135 adult female Wistar rats, cyclic loading of the ulna created stress fractures. Rats were treated daily with oral saline, or risedronate at 0.1 or 1.0 mg/kg. From each bone, histomorphometry was performed on sections stained with toluidine blue at a standard level along the fracture. The high dose of risedronate caused a significant decrease in the percentage of repaired stress fracture and bone resorption along the stress fracture line at 6 and 10 weeks after loading (p |
| Databáze: | OpenAIRE |
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