Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius
| Autor: | Jian-Min Yue, Sheng-Ping Yang, Zhaobing Gao, Yan Wu, Guo-Yuan Hu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
biology
Chemistry Stereochemistry Organic Chemistry Potassium channel blocker Selective inhibition Eupatorium chinense biology.organism_classification Biochemistry Chloranthus holostegius Delayed rectifier Chemical constituents Drug Discovery medicine Ic50 values Two-dimensional nuclear magnetic resonance spectroscopy medicine.drug |
| Zdroj: | Tetrahedron. 64:2027-2034 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2007.12.057 |
| Popis: | Four unusually fused polycyclic sesquiterpenoid dimers, chlorahololides C–F (1–4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra. Chlorahololides C–F (1–4) exerted potent and selective inhibition on the delayed rectifier (IK) K+ current with the IC50 values of 3.6±10.1, 2.7±0.3, 27.5±5.1 and 57.5±6.1 μM, respectively. |
| Databáze: | OpenAIRE |
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