The short-term effect and safety of duloxetine in osteoarthritis
| Autor: | Xi-Wen Li, Qi-Mou Pan, Hai-Yun Chen, Shi-Hua Gao, Jun-Han Huang, Jian-Bin Huo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
WOMAC business.industry General Medicine Placebo law.invention Discontinuation Clinical trial 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial chemistry law 030220 oncology & carcinogenesis Internal medicine Meta-analysis Relative risk Medicine Duloxetine 030212 general & internal medicine business |
| Zdroj: | Medicine. 98:e17541 |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | BACKGROUND Previous clinical trials indicated that duloxetine may be effective in the treatment of osteoarthritis (OA) pain. This meta-analysis is conducted to evaluate short term analgesic effect and safety of duloxetine in the treatment of OA. METHODS Electronic databases were searched in February 2019, including PUBMED, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Web of Science. All eligible studies should be randomized controlled trials (RCTs) comparing duloxetine treatment group to placebo about OA pain relief and safety outcomes. RESULTS Five RCTs with 2059 patients were involved in this systematic review and meta-analysis. Compared to placebo, duloxetine treatment showed significant better result, with higher reduction pain intensity (mean difference [MD] = -0.77, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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