Clinical features of liver dysfunction in collagen diseases
| Autor: | Atsushi Irisawa, Haruyo Iwadate, Junko Yokokawa, Hiromasa Ohira, Hiroko Kobayashi, Hiroshi Watanabe, Atsushi Takahashi, Kazumichi Abe |
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| Rok vydání: | 2010 |
| Předmět: |
Liver injury
Pathology medicine.medical_specialty Collagen disease Hepatology biology business.industry Fatty liver C-reactive protein Autoimmune hepatitis Dermatomyositis medicine.disease Infectious Diseases Primary biliary cirrhosis Mixed connective tissue disease biology.protein Medicine business |
| Zdroj: | Hepatology Research. 40:1092-1097 |
| ISSN: | 1386-6346 |
| DOI: | 10.1111/j.1872-034x.2010.00707.x |
| Popis: | Aim: Liver dysfunction is not rare in patients with collagen disease. We sought to elucidate the clinical features of liver dysfunction in the presence of collagen disease. Methods: We analyzed the frequency and causes of liver dysfunction in 607 patients (rheumatoid arthritis [RA], n = 220; systemic lupus erythematosus [SLE], n = 164; systemic sclerosis [SSc], n = 47; Sjogren's syndrome [SjS], n = 44; Behcet's disease, n = 43; polymyositis/dermatomyositis [PM/DM], n = 27; vasculitis syndrome, n = 25; mixed connective tissue disease [MCTD], n = 21; and adult-onset Still's disease [AOSD], n = 16). Results: Liver dysfunction was observed in 238 (39.2%) of 607 patients showing collagen disease. Patients with AOSD (81.3%), PM/DM (51.9%) and vasculitis syndrome (48.0%) frequently displayed liver dysfunction. Liver dysfunction in collagen diseases results from many causes; drug-induced liver injury (26.1%), fatty liver (7.6%), viral hepatitis (1.3%), autoimmune hepatitis (4.2%), primary biliary cirrhosis (15.9%) and the collagen disease itself (15.5%). Conversely, primary biliary cirrhosis was a leading cause in SSc (76.1%) and SjS (70.0%). Liver dysfunction in collagen disease tended to be mild. In addition, alanine aminotransferase levels correlated positively with ferritin levels in AOSD (R = 0.708, P |
| Databáze: | OpenAIRE |
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