Grape Powder Reverses Deleterious Effects of GLP‐1 Receptor Antagonism on Oral Glucose Tolerance in Mice
| Autor: | Katheryn M. Goodrich, Andrew D. Gilley, Thomas C. Haufe, Caroline Ryan, Andrew P. Neilson, Andrew T. Smithson |
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| Rok vydání: | 2015 |
| Předmět: |
endocrine system
business.industry medicine.drug_class digestive oral and skin physiology fungi Area under the curve food and beverages Pharmacology Receptor antagonist Biochemistry Genetics Medicine Secretion Oral glucose tolerance Receptor Antagonism business Molecular Biology Glucagon-like peptide 1 receptor Biotechnology Glycemic |
| Zdroj: | The FASEB Journal. 29 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.29.1_supplement.lb288 |
| Popis: | The mechanism by which grapes and grape flavan-3-ols improve glycemic control is poorly understood. Studies have shown that dietary flavan-3-ols may act in the gut to increase secretion of incretins such as glucagon-like peptide-1 (GLP-1). Our objectives were to determine the impact of grapes on GLP-1 signaling and acute glycemic control, and compare the effects of grape administration to the gut vs. peripheral tissues. The impact of a GLP-1 receptor antagonist (vs. vehicle) on oral glucose tolerance was studied in mice administered either grape powder (a substitute for fresh grapes) or control. Additionally, the effect of delivering grape (or control) orally vs. to the intraperitoneal (i.p.) cavity was examined. In control mice, GLP-1 receptor antagonism significantly increased oral glucose area under the curve (AUC) vs. vehicle. While grape powder did not lower AUC in vehicle-treated mice compared to vehicle-treated control, it did inhibit the deleterious effects of GLP-1 receptor antagonism compared to... |
| Databáze: | OpenAIRE |
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