An efficient synthesis and characterization of novel (Z)-1-phenyl(arylamino)methylpyrrolidine-2,5-dione derivatives as potential analgesic agents

Autor:	I. P. Yakovlev, Dar’ya V. Spiridonova, Elena V. Kuvaeva, Valery N. Yuskovets, Yulia A. Trukhanova, Denis A. Kolesnik, Tamara L. Semakova, Galina V. Ksenofontova
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry In vivo Succinic anhydride General Chemistry Carbon-13 NMR Medicinal chemistry Analgesic agents
Zdroj:	Chemical Data Collections. 35:100770
ISSN:	2405-8300
DOI:	10.1016/j.cdc.2021.100770
Popis:	The reaction of N-arylbenzenecarboximidamides 1a-e with succinic anhydride 2 was studied, leading to the formation of (Z)-1-phenyl(arylamino)methylpyrrolidine-2,5-diones 3a-e in good yields. The structure of the obtained compounds was proved by 1H, 13C NMR, IR, MS (ESI) and elemental analyzes. For (Z)-1-phenyl(phenylamino)methyl)pyrrolidine-2,5-dione 3a, an X-ray diffraction analysis was performed and an in vivo study of analgesic activity in laboratory mice was carried out.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e2deaafb5fc27461b144ebf9d2a9a3d https://doi.org/10.1016/j.cdc.2021.100770 Zobrazit plný text záznamu Full Text from ScienceDirect