Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome

Autor:	E. V. Semenova, Natalia B. Mikhailova, Boris V. Afanasyev, Andrey Yu. Zaritskey, L. S. Zoubarovskaya, Naoto T. Ueno, Gabriela Rondon, Richard E. Champlin, Susan O'Brien, Michael Andreeff, Athanasios Anagnostopoulos, O. S. Pankratova
Rok vydání:	2002
Předmět:	Melphalan medicine.medical_specialty Allogeneic transplantation Hypereosinophilic syndrome business.industry Hematology medicine.disease Fludarabine Surgery Transplantation medicine.anatomical_structure Immunopathology medicine Bone marrow business medicine.drug Preparative Regimen
Zdroj:	British Journal of Haematology. 119:131-134
ISSN:	0007-1048
Popis:	In this report, we describe two patients with idiopathic hypereosinophilic syndrome (HES) who received a non-myeloablative allogeneic transplantation following a reduced-intensity preparative regimen of melphalan and fludarabine. In both cases, complete donor chimaerism and remission were achieved, and have lasted for more than 10 months. This report provides proof of principle for the feasibility of non-myeloablative transplantation for patients with idiopathic HES, who can show co-morbidity due to eosinophilic infiltration of their organs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7db0ef3a606005808e426145092b2292 https://doi.org/10.1046/j.1365-2141.2002.03771.x Zobrazit plný text záznamu Plný text