Improved reproducibility of chemical reactions on purified polystyrene resins monitored by 31P MAS NMR

Autor:	René Steinauer, Roland Hany, Daniel Rentsch, Sophie Barthélémy
Rok vydání:	2003
Předmět:	Thermogravimetric analysis Reproducibility Organic Chemistry Biochemistry Chemical reaction chemistry.chemical_compound chemistry Drug Discovery Polymer chemistry medicine Organic synthesis Polystyrene Swelling medicine.symptom Nuclear chemistry Triphenyl phosphate
Zdroj:	Tetrahedron Letters. 44:6987-6990
ISSN:	0040-4039
Popis:	The use of polystyrene beads from different origins in solid-phase organic synthesis was investigated after a simple cleaning procedure of the starting material. The swelling and thermogravimetric properties and the reproducibility of a five-step reaction cascade were investigated. The resin loadings of polystyrene bound phosphines were quantitatively determined by 31 P MAS NMR via addition of triphenyl phosphate as reference compound and the loadings of intermediate products were evaluated by Fmoc cleavage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7dabb3448ef9511d1e9aeab9d7f3ebea https://doi.org/10.1016/s0040-4039(03)01803-3 Zobrazit plný text záznamu Full Text from ScienceDirect