Eco-friendly one-pot, three-component synthesis of novel derivatives of kojic acid by the Mannich-type reaction under solvent-free ball-milling conditions
| Autor: | Naser Arsalani, Reza Teimuri-Mofrad, Aziz Shahrisa, Mahdi Gholamhosseini-Nazari |
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| Rok vydání: | 2015 |
| Předmět: |
010405 organic chemistry
Component (thermodynamics) Condensation chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Environmentally friendly 0104 chemical sciences Catalysis Cerium chemistry.chemical_compound chemistry Acetone Organic chemistry Kojic acid Ball mill |
| Zdroj: | Research on Chemical Intermediates. 42:3425-3439 |
| ISSN: | 1568-5675 0922-6168 |
| DOI: | 10.1007/s11164-015-2221-0 |
| Popis: | A novel series of aminokojic acid derivatives were efficiently synthesized by one-pot condensation of kojic acid, aromatic aldehydes and heteroaromatic amines in the presence of cerium(III) sulphate as an efficient and recyclable catalyst in ball-milling under solvent-free conditions at room temperature. This synthesis method offers several advantages, including a green and eco-friendly protocol, operational simplicity, mild reaction conditions, short reaction time, higher yields and easy workup procedures. The workup of these very clean reactions involves only a simple washing with acetone/cold water. The catalytic system can be reused several times with no loss of activity. |
| Databáze: | OpenAIRE |
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