Evidence-Based Update on Ocular Chemical Injuries
| Autor: | Donald U. Stone, Karam Hamweyah |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Doxycycline medicine.medical_specialty Evidence-based practice Conjunctiva Keratoprosthesis business.industry Surgery 03 medical and health sciences Ophthalmology 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Cornea 030221 ophthalmology & optometry medicine Oral vitamin business Ocular surface Chemical Injury medicine.drug |
| Zdroj: | Current Ophthalmology Reports. 5:49-57 |
| ISSN: | 2167-4868 |
| DOI: | 10.1007/s40135-017-0120-9 |
| Popis: | Chemical injuries of the eye remain a serious cause of visual disability. The current literature is reviewed, with a focus on recent studies that inform evidence-based treatment decisions. Prevention continues to be a primary goal. In addition to conventional therapy (urgent irrigation, topical corticosteroids and antibiotics, oral vitamin C, possibly doxycycline and topical antioxidants), there is evidence that amniotic membrane, umbilical cord serum, or platelet-rich plasma may improve epithelial healing rates in moderate to severe burns. Reconstruction of the ocular surface continues to evolve; for unilateral disease, simple limbal epithelial transplant (SLET) is gaining momentum. For bilateral total limbal stem cell deficiency, treatment options include allogeneic keratolimbal allograft, ex vivo expansion of cultured epithelial sheets, and keratoprosthesis; each intervention represents a unique balance of risks and benefits. SLET appears to be simple and effective for unilateral limbal stem cell deficiency secondary to chemical injuries. The treatment of bilateral injuries requires additional studies to define the preferred practice patterns, as there is no clear consensus regarding the preferred intervention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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