A novel hemostat and antibacterial nanofibrous scaffold based on poly(vinyl alcohol)/poly(lactic acid)
| Autor: | Ramin Khajavi, Reyhaneh Fatahian, Mohammad Mirjalili, Navid Nasirizadeh, Mohammad Karim Rahimi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hemostat
Vinyl alcohol integumentary system Polymers and Plastics Bioengineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Electrospinning 0104 chemical sciences Lactic acid Biomaterials chemistry.chemical_compound Polylactic acid chemistry Wound dressing Nanofiber Materials Chemistry Organic chemistry 0210 nano-technology Antibacterial activity |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 35:189-202 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/0883911520913900 |
| Popis: | Today, an advanced wound dressing with the ability of blood clotting and antibacterial activity is the main subject of many studies to consider their necessity in modern society. In this study, it was aimed to present a novel scaffold with both abilities simultaneously. Poly(vinyl alcohol)/poly(lactic acid) nanofibrous scaffolds containing ceftriaxone antimicrobial agent (PVA-CTX/PLA) and tranexamic acid coagulant (PVA-CTX-TXA/PLA) were fabricated by electrospinning method. Morphology, antimicrobial activity, blood coagulation and bioavailability indexes, and swelling ability (gel formation) of produced samples were determined. Morphological results showed that the hybrid nanofibers were form successfully. The antibacterial efficiency of them against Gram-negative ( Escherichia coli) and Gram-positive ( Staphylococcus aureus) bacteria was more than 90% for PVA-CTX/PLA and it reached 100% for PVA-CTX-TXA/PLA. Both PVA-CTX-TXA/PLA and PVA-TXA/PLA scaffolds showed acceptable blood coagulation ability with an average absorption of 0.043 and 0.036 nm, respectively. PVA-CTX-TXA/PLA scaffolds had a gel formation ability of about 45 min. All scaffolds were successful in cell proliferation (L929 fibroblast cell) after 48 h. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|