Gammagrafía con 75SeHCAT en la diarrea crónica por malabsorción de ácidos biliares
| Autor: | L.M. Mena Bares, E. Iglesias Flores, E. Moreno Ortega, E. Carmona Asenjo, J.A. Vallejo Casas, J.M. Benítez Cantero, F.R. Maza Muret, M.V. Guiote Moreno, M.V. García Sánchez, A.M. Santos Bueno |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cholestyramine Bile acid medicine.drug_class Colesevelam business.industry food and beverages Bile acid malabsorption FGF19 medicine.disease Gastroenterology 030218 nuclear medicine & medical imaging Surgery 03 medical and health sciences 0302 clinical medicine Tolerability Bile acid sequestrant Internal medicine medicine 030211 gastroenterology & hepatology Radiology Nuclear Medicine and imaging business Enterohepatic circulation medicine.drug |
| Zdroj: | Revista Española de Medicina Nuclear e Imagen Molecular. 36:37-47 |
| ISSN: | 2253-654X |
| Popis: | Chronic diarrhoea is a common entity in daily clinical practice and it leads to a loss in these patients quality of life. It may be the main symptom of multiple ethiologies including bile acid malabsorption (BAM) which has a comparable prevalence to celiac disease. The BAM results from imbalances in the homeostasis of bile acids in the enterohepatic circulation. It can be a consequence of ileal disease or ileal dysfunction (BAM type i), it can be considered idiopathic or primary (BAM type ii) or associated with other gastrointestinal entities (BAM type iii). Among the different diagnostic methods available, 75SeHCAT study is the primary current method due to its sensitivity, specificity, safety and low cost. The main disadvantage is that it's not available in all countries, so other diagnostic methods have appeared, such as serum measurement of FGF19 and C4, however they are significantly more complex and costly. The first-line treatment of bile acid diarrhoea is bile acid sequestrant, such as cholestyramine, which can be difficult to administer due to its poor tolerability and gastrointestinal side effects. These are less prominent with newer agents such as colesevelam. In summary, the BAM is a common entity underdiagnosed and undertreated, so it is essential to establish a diagnosis algorithm of chronic diarrhoea in which the 75SeHCAT study would be first or second line in the differential diagnosis of these patients. |
| Databáze: | OpenAIRE |
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