RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway
| Autor: | Yanqing Ding, Ling-Jie Zhang, Fang-Yi Han, Hong-Li Jiao, Dan Zhang, Wen-Feng He, Jiong-Hua Zhu, Shu-Yang Wang, Sheng-Nan Li, Guang-Hua Liang, Bin-Shu Weng, Wei-Yi Zhao, Xiao-Qing Li, Ya-Ping Ye, Li-Jie Chen, Zi-Mo Lin, Shan-Shan Yan, Xiao-Ping Chen, Jia-Yi Huang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research business.industry Colorectal cancer Immunology Cell Biology Hypoxia (medical) medicine.disease digestive system diseases In vitro Metastasis 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine HIF1A Downregulation and upregulation Ras Signaling Pathway In vivo 030220 oncology & carcinogenesis Cancer research Medicine medicine.symptom business |
| Zdroj: | Cell Death & Disease. 11 |
| ISSN: | 2041-4889 |
| DOI: | 10.1038/s41419-020-02793-3 |
| Popis: | Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the role of OSBPL3 in the proliferation, invasion and metastasis of CRC remains unclear. In this study, we investigated the role of OSBPL3 in CRC and found that its expression was significantly higher in CRC tissues than that in normal tissues. In addition, high expression of OSBPL3 was closely related to poor differentiation, advanced TNM stage and poor prognosis of CRC. Further experiments showed that over-expression of OSBPL3 promoted the proliferation, invasion and metastasis of CRC in vitro and in vivo models. Moreover, we revealed that OSBPL3 promoted CRC progression through activation of RAS signaling pathway. Furthermore, we demonstrated that hypoxia induced factor 1 (HIF-1A) can regulate the expression of OSBPL3 via binding to the hypoxia response element (HRE) in the promoter of OSBPL3. In summary, Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway. This novel mechanism provides a comprehensive understanding of both OSBPL3 and the RAS signaling pathway in the progression of CRC and indicates that the HIF1A–OSBPL3–RAS axis is a potential target for early therapeutic intervention in CRC progression. |
| Databáze: | OpenAIRE |
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