AlCl3-Mediated Synthesis of 4-Aryl-2-quinolone-3-carboxylates
| Autor: | Seung-Hye Yang, Dongyun Shin, Seohyun Jo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Reaction conditions
010405 organic chemistry Aryl Organic Chemistry Intramolecular cyclization 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Nitrobenzene chemistry.chemical_compound 2-quinolone chemistry Intramolecular force Organic chemistry Lewis acids and bases |
| Zdroj: | Synlett. 28:1614-1619 |
| ISSN: | 1437-2096 0936-5214 |
| DOI: | 10.1055/s-0036-1588798 |
| Popis: | 4-Aryl-2-quinolones are important skeletons from both chemical and medicinal viewpoints. We herein report the development of an efficient synthetic method for 3-substituted 4-aryl-2-quinolones. The key reaction in this process involves an AlCl3-mediated intramolecular cyclization of substituted 2-(carbamoyl)-3-phenylacrylates, with optimized reaction conditions of 2.0 equivalents of AlCl3, nitrobenzene, 80 °C, and 3 hours. The chemical yields of cyclization were found to be sensitive to all reaction conditions. |
| Databáze: | OpenAIRE |
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