Palladium-catalyzed diastereoselective hydrogenation of N-substituted 3-methyleneisoindolin-1-ones

Autor:	Zh. R. Sagirova, E. V. Starodubtseva, O. V. Turova, M. G. Vinogradov
Rok vydání:	2012
Předmět:	chemistry.chemical_compound Chemistry Enantioselective synthesis Noyori asymmetric hydrogenation chemistry.chemical_element Organic chemistry General Chemistry Methanol Cinchonidine Palladium catalyst Catalysis Palladium
Zdroj:	Russian Chemical Bulletin. 61:1133-1137
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-012-0154-y
Popis:	An asymmetric synthesis of chiral N-substituted 3-methylisoindolin-1-ones was performed using the Pd0-catalyzed diastereoselective hydrogenation of their 3-methylene-substituted precursors, that has not been investigated earlier. The highest diastereoselectivity (67% de) was achieved when the hydrogenation was carried out in methanol mediated by a palladium catalyst (Pd/C) modified with cinchonidine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ba2d64784daf75bb0c168f2da434cbf https://doi.org/10.1007/s11172-012-0154-y Zobrazit plný text záznamu Full text from SpringerLink