Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)

Autor:	Zhihui Peng, Robert A. Singer, David B. Damon, Lulin Wei, Emma McInturff, Bryan Li, Stephen W. Wright, David Place
Rok vydání:	2018
Předmět:	Materials science Scale (ratio) 010405 organic chemistry medicine.drug_class Organic Chemistry Carboxamide Sulfoxide 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry medicine Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 22:1835-1845
ISSN:	1520-586X 1083-6160
Popis:	An improved process for the large scale synthesis of 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (1), a candidate currently in clinical develop...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b937cd8895072f98d3e1bdf71fec919 https://doi.org/10.1021/acs.oprd.8b00386 Zobrazit plný text záznamu