Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease
Autor: | Barton F. Haynes, Louis F. Diehl, John J. Hooks, Anthony S. Fauci, Barbara Detrick-Hooks, Theresa L. Gerrard |
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Rok vydání: | 1982 |
Předmět: | |
Zdroj: | Blood. 59:198-201 |
ISSN: | 1528-0020 0006-4971 |
Popis: | We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral lymphocytes consisted of 95% TG cells, which exhibited the morphological characteristics of T- cell chronic lymphocytic leukemia (CLL) and were normal on cytochemical and chromosome analysis. The majority of TG cells were OKT3+, OKT8+, and OKT4-, 3A1-. These cells failed to express suppressor cell activity and displayed depressed levels of natural killer activity, but mediated antibody-dependent cell-mediated cytotoxicity. The spontaneous production of IFN-gamma by human peripheral lymphoid cells as demonstrated in this study may serve as a probe for studying the relationship between IFN-gamma and the proliferation of human T-cell subsets. |
Databáze: | OpenAIRE |
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