Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β-cell dysfunction

Autor:	Nathalie Esser, Stephen M. Mongovin, Jacqueline Parilla, Breanne M. Barrow, Thomas O. Mundinger, Brendy S. Fountaine, Megan J. Larmore, Joseph J. Castillo, Rehana Akter, Rebecca L. Hull, Sakeneh Zraika
Rok vydání:	2022
Předmět:	Physiology Physiology (medical) Endocrinology Diabetes and Metabolism fungi
Zdroj:	American Journal of Physiology-Endocrinology and Metabolism. 322:E307-E318
ISSN:	1522-1555 0193-1849
DOI:	10.1152/ajpendo.00234.2021
Popis:	The neprilysin inhibitor, sacubitril, improves glycemic status in a mouse model of reduced insulin secretion. Sacubitril enhances intravenous but not oral glucose-mediated insulin secretion. The increased glucose-mediated insulin secretion is GLP-1 receptor-dependent. Neprilysin inhibition does not raise postprandial circulating active GLP-1 levels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7b7a38cdff715869db9c71f679e2e833 https://doi.org/10.1152/ajpendo.00234.2021 Zobrazit plný text záznamu