Cucurbit[n]urils (n = 6–8) used as host molecules on supramolecular complexes formed with two different drugs: Emodin and indomethacin
| Autor: | Santiago Sánchez-Cortés, Paz Sevilla, Margarita Hernández, Elisa Corda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Aqueous solution
Supramolecular chemistry macromolecular substances 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Colloid and Surface Chemistry chemistry Drug delivery Proton NMR Molecule Solubility Emodin 0210 nano-technology Stoichiometry |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 557:66-75 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2018.04.068 |
| Popis: | We present the characterization of supramolecular complexes formed by cucurbit[n]urils, (n = 6,7,8) with the anti-tumoral drug emodin and the non-steroidal anti-inflammatory drug indomethacin at several pHs. Both drugs exhibit poor water solubility and host-guest complexes constitute an option to increase the drugs’ solubility and stability. We use different spectroscopic techniques: UV–vis, 1H NMR and fluorescence. Our study shows that emodin forms complexes at pH = 2 with cucurbit[6]uril with stoichiometry (1:1) (host:guest), as well as complexes with cucurbit[7]uril and cucurbit[8]uril with stoichiometry (2:1) but no complexes are found at basic pHs. In the case of indomethacin, complexes are formed with cucurbit[6]uril and cucurbit[8]uril at pH = 6, with stoichiometries (2:1) and (1:1) respectively. The data presented here can be useful in the development of new drug delivery systems employing these supramolecular assemblies. |
| Databáze: | OpenAIRE |
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