| Autor: |
Dmitrii Fedoseenko, Aleksei Nazarenko, Sergei Tkachev, Ivanov Sm, D. S. Romanov, Sergey Medvedev, T. N. Borisova, Irina Grishina, Oksana Trofimova, Sevil Alieva, Lidiia Rotobelskaia, Abror Abduzhapparov, Valeriia Glebovskaia |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Problems in oncology. 67:382-390 |
| ISSN: |
0507-3758 |
| DOI: |
10.37469/0507-3758-2021-67-3-382-390 |
| Popis: |
Stereotactic body radiation therapy currently occupies its place in the complex treatment of cancer patients with liver metastases. It is assumed that certain groups of patients with breast cancer can benefit from the use of this method, which can be converted into improved overall survival and survival rates without signs of progression of the process. Purpose of the study was to evaluate the efficacy and tolerability of stereotactic radiotherapy in patients with breast cancer metastases in the liver. We have analyzed the results of using stereotactic radiotherapy in 25 breast cancer patients with 43 liver metastases. The treatment was carried out in 3 fractions with a fraction dose of 10-15 Gy and a total dose of 30-45 Gy. Growth of the irradiated lesions was recorded only in 1 case out of 43 metastases (2,3%) and 25 (4%) patients. 1-, 3- and 5-year overall survival rates from the moment of stereotactic radiotherapy were 82,9%, 62% and 38,7%, respectively. Long-term post-radiation adverse events were observed in 8% of cases and did not have a significant effect on the quality of life and the possibility of antitumor treatment. So stereotactic radiotherapy can be recommended as a relatively safe and highly effective method of elimination of breast cancer liver metastases. Taking into account the high achieved local control, further studies on dose escalation in this group of patients are not required. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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