La leptine : un modulateur de l’activité des cellules Natural Killer ?
| Autor: | Ahmad Khalil, Bruno Lamas, Marie-Chantal Farges, Marie-Paule Vasson, Sinda Mahbouli |
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| Rok vydání: | 2015 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Nutrition and Dietetics Innate immune system Endocrinology Diabetes and Metabolism Leptin digestive oral and skin physiology Cell Biology medicine.disease_cause In vitro 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology Lytic cycle Internal medicine Internal Medicine medicine Cytotoxic T cell Cytotoxicity Carcinogenesis hormones hormone substitutes and hormone antagonists 030304 developmental biology 030215 immunology |
| Zdroj: | Nutrition Clinique et Métabolisme. 29:12-25 |
| ISSN: | 0985-0562 |
| DOI: | 10.1016/j.nupar.2014.10.002 |
| Popis: | Natural Killer (NK) cells are not just cytotoxic effectors of the innate immune response against tumors and infections but also important immunoregulators. They are activated by an intricate balance between signals provided by their inhibitory and activating receptors. Leptin, one major metabolic factor produced by adipocytes, appears to be strongly involved in obesity-induced dysimmunity and carcinogenesis. This paper reviews the studies investigating the effect of leptin on NK cells. Leptin, at level similar to that found in obesity, stimulate, in vitro, both the NK cell metabolic and lytic activities. In contrast, no significant association was observed, in vivo, between serum leptin and NK cytotoxicity whatever the model, diet-induced or constitutive obesity. These findings may be related to leptin resistance. |
| Databáze: | OpenAIRE |
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