OBSERVATIONS CONCERNING THE PRODUCTION AND EXCRETION OF CHOLESTEROL IN MAMMALS

Autor:	Barbara Gunning, Meyer Friedman, Max W. Biggs, Sanford O. Byers
Rok vydání:	1953
Předmět:	medicine.medical_specialty Cholesterol Immunology Cholic acid Blood proteins Excretion chemistry.chemical_compound Endocrinology Blood chemistry chemistry Internal medicine Blood plasma medicine Immunology and Allergy Sodium Cholate Ligation
Zdroj:	Journal of Experimental Medicine. 97:511-524
ISSN:	1540-9538 0022-1007
DOI:	10.1084/jem.97.4.511
Popis:	Accumulation of cholate in plasma is the immediate cause of hypercholesteremia in the rat with bile duct ligation and in the normal rat given intravenous sodium cholate. The hypercholesteremia induced by cholate administration does not appear to be dependent upon any preceding change in the rates of absorption, excretion, synthesis, or redistribution of cholesterol in the tissues of the animal. Cholate administration seems to induce hypercholesteremia by impeding the normal rate of passage of cholesterol from the plasma into the liver; this impedance is probably due to an alteration of the cholesterol-binding power of plasma proteins induced by cholate. The chemical and physiological implications of this finding are discussed.
Databáze:	OpenAIRE
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