Benefits and risks evaluation of recombinant human growth hormone replacement therapy in children with GHD after craniopharyngioma surgery

Autor:	Li-li Pei, Ying Guo, Han Chen, Li-Yong Zhong
Rok vydání:	2023
Předmět:	Endocrinology Endocrinology Diabetes and Metabolism Pediatrics Perinatology and Child Health
Zdroj:	Journal of Pediatric Endocrinology and Metabolism. 36:484-491
ISSN:	2191-0251 0334-018X
DOI:	10.1515/jpem-2022-0605
Popis:	Objectives Childhood-onset craniopharyngiomas (CPs) have a high incidence of growth hormone deficiency (GHD) leading to growth failure and metabolic disorders. We aim to evaluate the benefits and risks of recombinant human growth hormone replacement therapy (GHRT) in postoperative children. Methods We retrospectively analyzed auxological and metabolic parameters and adverse events before and after GHRT of 44 children after CP surgery. Results The median duration of GHRT was 24 months (IQR, 12.5–36). Growth velocity (GV) increased significantly after different treatment duration (TD) compared with baseline (p Conclusions GHRT effectively accelerates GV, increases HtSDS, and improves lipid profiles without unfavorable effects on glucose metabolism. The benefits are clear and the risks of adverse events are low.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7a74598a90176221f2536c24cf8c8eff https://doi.org/10.1515/jpem-2022-0605 Zobrazit plný text záznamu