174 EVALUATION OF SUBCLINICAL RIGHT VENTRICULAR CARDIOTOXICITY BY ADVANCED ECHOCARDIOGRAPHY IN PATIENTS WITH BREAST CANCER TREATED WITH ANTHRACYCLINES

Autor: Grazia Gambino, Daniela Di Lisi, Antonio Di Palermo, Oreste Fabio Triolo, Ludovico Rossetto, Rita Cristina Myriam Intravaia, Giancarlo Buccheri, Giulia Passavanti, Alfredo Ruggero Galassi, Giuseppina Novo
Rok vydání: 2022
Předmět:
Zdroj: European Heart Journal Supplements. 24
ISSN: 1554-2815
1520-765X
Popis: Background Chemotherapeutic drugs may cause many complications affecting the cardiovascular system. There is a strong evidence suggesting the impact of this drugs on the left ventricle (LV), whereas less data regarding cardiotoxicity on the right ventricle (RV) exist. Purpose The aim of this study was to intercept early subclinical RV changes in patients treated with anthracyclines, using advanced echocardiography, with the hope that these could potentially be used to predict ventricular dysfunction. Methods In our single-center study, 20 female patients with breast cancer treated with anthracyclines were enrolled from 2019 to 2021. Cardiological evaluation and echocardiogram were performed at baseline (T0), 3 months (T1) and 6 months (T2) after initiation of chemotherapy. RV systolic function was calculated by estimation of conventional 2D echocardiographic and Doppler parameters (TAPSE, S’RV, FAC). Advanced echocardiography evaluation of right ventricular function was performed to quantify the following parameters: 3D right ventricular end-diastolic volume (RVEDV), 3D end-systolic volume (RVESV), 3D stroke volume (RVSV), 3D ejection fraction (RVEF), global longitudinal strain of the RV (RVGLS) and longitudinal free wall strain of the RV (RVLFS). Results Only 2 patients developed cardiotoxicity according to the criteria of the 2022 ESC Guidelines. Regarding the impact of chemotherapy on RV function, no statistically significant changes were found in conventional echocardiographic parameters (TAPSE, S’RV, FAC). In contrast, speckle tracking analysis of the RV showed a statistically significant reduction in both global strain [global RVGLS -23.3 ± 2.2% at T0 vs -19.5 ± 10.9% at T1 (p Conclusions RV speckle tracking and 3D echocardiography seemed to intercept subclinical damage due to anthracyclines earlier than conventional parameters. Further studies are needed to confirm our results and to evaluate their prognostic impact.
Databáze: OpenAIRE
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