Autor: | C. J. De Blaey, H.J.M. Beijer |
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Rok vydání: | 2002 |
Předmět: |
Pharmacology
Pediatrics medicine.medical_specialty business.industry Public health MEDLINE Pharmaceutical Science Pharmacy Subgroup analysis social sciences General Medicine Toxicology humanities Meta-analysis Health care Epidemiology Emergency medicine medicine Pharmacology (medical) Observational study business |
Zdroj: | Pharmacy World and Science. 24:46-54 |
ISSN: | 0928-1231 |
Popis: | Aim: to establish the percentage hospital admission related to adverse drug reactions (ADRs) from the data available in the literature. Method: literature search in the Medline database, metaanalysis. Results: from the literature it is revealed that a considerable part of all hospital admissions are related to adverse drug reactions. However, these data are not homogenous, i.e. larger studies display a lower percentage of ADR related hospital admission, while smaller studies display a higher percentage. Subgroup analysis showed that for elderly people the odds of being hospitalised by ADR related problems is 4 times higher than for younger ones (16.6% vs. 4.1%). A considerable part of these hospitalisations can be prevented. Subgroup analysis revealed that in the elderly up to 88% of the ADR related hospitalisations are preventable; for the non-elderly this is only 24%. Comparatively more elderly people are hospitalised than younger ones. Combining these findings, twice as much elderly people are hospitalised by ADR related problems than non-elderly, while preventability of ADR related hospitalisation might yield 7 times more people in the elderly than in the non-elderly. The estimation of the costs of ADR related hospitalisations in the Health Care system in The Netherlands is discussed. Conclusion: many elderly people are hospitalised by ADR related problems; an important part of these hospitalisations can be avoided. |
Databáze: | OpenAIRE |
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