Early-Onset Colorectal Cancer Is Associated with a Lower Risk of Metachronous Advanced Neoplasia than Traditional-Onset Colorectal Cancer
| Autor: | Vivy T. Cusumano, Liu Yang, Michelle C. Chong, Diana Partida, Jonathan K. Lin, Frank W. Chen, Folasade P. May |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology Colorectal cancer Proportional hazards model business.industry Incidence (epidemiology) Gastroenterology Retrospective cohort study Hepatology medicine.disease Lower risk digestive system diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology Family history Prospective cohort study business neoplasms |
| Zdroj: | Digestive Diseases and Sciences. 67:1045-1053 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-021-06902-w |
| Popis: | Colorectal cancer (CRC) incidence in the USA has increased in adults under age 50. Current CRC surveillance guidelines do not consider age at diagnosis, and there are limited data available on outcomes from surveillance colonoscopies in early-onset CRC (EO-CRC) to guide recommendations on surveillance intervals. To compare surveillance outcomes between EO-CRC and traditional-onset colorectal cancer (TO-CRC). In a retrospective cohort study in a large tertiary care academic medical center, we collected data on patients with a diagnosis of CRC between 2000 and 2014 who received surgery with curative intent. We used log-rank test and inverse probability of treatment weighted Cox regression analysis to compare the development of metachronous advanced neoplasia (MAN) in patients with EO-CRC (diagnosed ages 18–49) and TO-CRC (diagnosed ages 50–75). Patients with EO-CRC (n = 107) were more likely to present with advanced-stage disease (62% versus 35%, p |
| Databáze: | OpenAIRE |
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