Chemoselective Palladium-Catalyzed Direct C-H Arylation of 5-Carboxyimidazoles: Unparalleled Access to Fused Imidazole-Based Tricycles Containing Six-, Seven- or Eight-Membered Rings

Autor:	Cédric Schneider, Christophe Hoarau, Patrick René Angibaud, Jérémy Thireau, Vincent Levacher, Sandrine Gaurrand, Christine Baudequin, Lieven Meerpoel, Olivier Alexis Georges Querolle
Rok vydání:	2017
Předmět:	chemistry.chemical_classification 010405 organic chemistry Organic Chemistry chemistry.chemical_element Halide 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis Solvent chemistry.chemical_compound chemistry Intramolecular force Organic chemistry Imidazole Physical and Theoretical Chemistry Tricyclic Palladium
Zdroj:	European Journal of Organic Chemistry. 2017:2491-2494
ISSN:	1434-193X
Popis:	An extensive study of the chemoselective Pd-catalyzed inter- and intramolecular direct C–H arylation of N-benzylated 5-carboxyimidazoles with halides with and without CuI assistance in 1,4-dioxane as a low-polarity solvent was explored. The method was suitable for the synthesis of fused imidazole-based tricyclic systems incorporating medium-sized rings, including, for the first time, eight-membered rings, which are valuable in modern drug design.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::797e39d542889eb204892a6973621bd5 https://doi.org/10.1002/ejoc.201700297 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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